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Welcome to the Research Department
I have recently joined MCSRC as Head, Research Centre, and I am privileged to be associated with this institute which is imparting world class treatment to cancer patients at affordable cost. The working environment of scientists, other support staff of the department, supporting staffs is very effective for in-depth research. The lab infrastructure is excellent with state of art instruments for research in clinical research as well as research in genetics of cancer.

I welcome all the Scientists, Researchers and Students who want to pursue research training from this esteemed institute. They will be supported by high class academic education and support in research training.

I'm most proud of the blessings that God has bestowed upon me to serve MCSRC in my life time.

Prof. Ashok Kumar Ghosh

 
 
MCSRC Research Themes:
In order to harness the full potential of its investigative efforts, the Research Centre organizes research along seven cohesive themes:
 
Cancer and Arsenic
Gallbladder adenocarcinoma is one of the lethal cancers in human owing to both late presentation and an aggressive natural history. Northern and eastern states of India along the banks of river Ganga witness an exceptionally high incidence of Gall Bladder cancer. It is this Gangetic belt that is known to have very high levels of Arsenic in ground water, sometimes as high as 10-100 times permissible limits set by the WHO for water safe for human consumption. The department of Surgical Oncology and Research Centre have undertaken a study to find a link between raised arsenic level in water and Gall bladder cancer. This study probably will direct us to better understanding of arsenic related risk factors in subset of population at risk.
 
Tumour Marker Development
Tumor markers are substances that are produced by cancer or by other cells of the body in response to cancer or certain benign (noncancerous) conditions. Most tumor markers are made by normal cells as well as by cancer cells; however, they are produced at much higher levels in cancerous conditions. These substances can be found in the blood, urine, stool, tumor tissue, or other tissues or bodily fluids of some patients with cancer. Most tumor markers are proteins. The research team is presently working on development of tumour marker for Gall bladder cancer against conventional tumour marker CA 19.9.
 
Toxicology and Drug Discovery
Preclinical development encompasses the activities that link drug discovery in the laboratory to initiation of human clinical trials. Preclinical studies is designed to identify a lead candidate from several hits; develop the best procedure for new drug scale-up; select the best formulation; determine the route, frequency, and duration of exposure; and ultimately support the intended clinical trial design. The details of each preclinical development package can vary, but all have some common features. Mouse and Rat models have been used to delineate the pharmacokinetic profile and general safety, as well as to identify toxicity patterns. They are also used to determine the drug's mean residence time in the body, which depends on inherent absorption, distribution, metabolism, and excretion properties. The research team is engaged in development of drugs against Cancer, Diabetes and development of antidotes against toxicants.
Various preclinical study are done for the toxicological evaluation of various chemicals which are causing health hazards in humans. Assessment of Pesticides & Heavy metals in human blood & tissue samples, water, soil & food samples through HPLC & AAS.

 
Molecular Oncology
The molecular oncology in the institute deals -
• To describe the nature of cancer
• To review the causes of cancer
• To distinguish the biochemistry of normal and cancer tissue
• To consider the treatment of cancer
• To discuss measures for the prevention of cancer
• Molecular diagnostics is a dynamic and transformative area of diagnostics, leading to insights in research and treatment in many disease states that are revolutionizing health care.
In the present era, molecular diagnostics helps to make genetic profiling of tumour, which is standard part of medical care and allows physicians to determine which medications will work best for a particular patient. Targeted and customized therapies can be more effective at shrinking cancer tumour and reducing side-effects and recurrences. Cancer investigation through molecular diagnostics will pave the way in new dimension and more convenient to understand the nature of malignant cells. The Molecular Diagnostics will improve the line of cancer treatment. Since small alterations frequently occur in carcinomas and molecular diagnostics is a favourable option for the analysis of cancer markers. KRAS, NRAS, PIK3CA , EGFR, BCR/ABL, PML RARA and HER2neu are the markers for identification of particular medicine for a particular person. Molecular markers can stratify response groups and helps to choose right drug at right time with maximum efficacy and minimum adverse effect. The institute is in the final process of establishment of Molecular Diagnostic laboratory.
 
Karyotyping

Cancer is a genetic disease, caused by genomic mutations leading to the aberrant function of genes. Those mutations ultimately give cancer cells their proliferative nature. Hence, inferring the evolution of these mutations is an important problem in the research of cancer. Chromosomal mutations that shuffle/ delete/ duplicate large genomic fragments are common in cancer. Many methods for detection of chromosomal mutations use chromosome painting techniques, such as G banding, to achieve a visualization of cancer cell genomes.
A virtual karyotype can be generated from different tumor. We are doing karyotyping for detection of genotoxicity of different environmental pollutant including arsenic and pesticide toxicity in pre-clinical study also. We have prepared chromosomal map for our experimental animal Swiss albino mice.

 
Metabolic Disorders
Diabetes mellitus currently is a major health problem for the people of the world. It is a chronic metabolic disorder resulting from a variable interaction of hereditary and environmental factors and is characterized by abnormal insulin secretion or insulin receptor affecting β cells of pancreas. Diabetes mellitus affects a large number of people throughout the world and more so in India. In Mahavir Cancer Institute and Research Centre we are working on its remedial part with the use of 15 different medicinal plant extract including Nigella sativa, Brassica alba, Cinnamonum cassia, Aloe vera, Moringa oliferia, Vinca rosea, withania somnifera, Ocimum sanctum, Tinospora cordifolia, Zingiber officinale etc. we are studing on biochemical, haematological, hormonal and histological parameters for study on diabetes. We are also working on common factors between diabetes and cancer and how diabetes affects cancer.
 
Medicinal Chemistry
Many medicinal substances are temperature sensitive, it is vital that the correct temperature control equipment is used to separate active ingredient of medicinal plants. Rotary evaporators effectively separate one or more specific solvents from suspension using a combination of both endothermic evaporation and exothermic condensation because it is temperature dependent system. In order to ensure that the compound of interest is effectively separated, the evaporation temperature must be accurately maintained, making temperature controlled water an integral component. During the condensation phase, cooling must be accurately controlled by condensation unit. Through Rota vapour we will fractionate medicinal plants on the basis of polarity. Still we are working on more than 20 medicinal plants in our lab.
In second stage the fractionated substances were subjected to High Performance Liquid Chromatography (HPLC) for isolation of active ingredient of that medicinal plant. HPLC will be useful for classification of medicinal chemistry of selected medicinal plants.
Various medicinal plants are being studied as antidotes against pesticides, heavy metal toxicity& immunomodulation study against cancer chemotherapy. At this centre bio-remedial approach for treating Cancer is performed with the help of different medicinal plants either in separate form or synergistic form.

 
Researchers
Within the excellent facilities a group of Research Scientists and Doctors are carrying out research work using latest techniques on sophisticated instruments. The Research Centre provides a conducive workplace, supporting researchers as they pioneer together towards new scientific breakthroughs in the fight against cancer.
The MCSRC Centre facilitates the support of outstanding and devoted students at the forefront of research innovation. The Centre maintains very close bonds with the other departments of institute providing first-rate academic infrastructure required for the training and management of its students and researchers.
All research members have access to common areas, cutting edge equipment, core facilities and resources.

 
Research Laboratories

The Research Centre has 4 Laboratories and one Animal House with required facilities-

 
• Specialized Laboratory Instruments for Research
 
Laboratory- 1  
Atomic Absorption Spectrophotometer:  
(AAS Pinnacle 90T) with 8 Lamps for estimation of Heavy Metals (Arsenic, Lead, Cadmium, Mercury, Iron, Aluminum etc.). The instrument is utilized for assessment of heavy metals in blood and tissue samples of Cancer patients, Arsenic hit area village people etc.
 
     
 
Laboratory- 2  
High Pressure Liquid Chromatograph (HPLC):  
The instrument is utilized for estimation of Organochlorine and Organophosphate pesticides. It is also used in Medicinal Chemistry and Drug Delivery.
 
     
 
Rota Vapour:  
This machine is utilized for separation of polar and Non-polar compounds. This novel machine is used in Medicinal Chemistry.
 
     
 
U.V Vis Spectrophotometer:  
This instrument is utilized for Biochemical assay, Antioxidant assay and Reactive Oxygen Species assay in blood & tissues samples of Cancer patients.
 
   
 
Electrophoresis:  
The instrument is utilized for the molecular biology study on DNA and Proteins.
 
   
 
Laboratory- 3  
Digital Microtome:  
The instrument is utilized for pathological tissue study of Animal samples.
 
   
 
Digital Cooling Centrifuge :  
The instrument is utilized for various biochemical studies
 
   
 
Digital Deep Freezer:  
The instrument with – 80 Degree Celsius temperature is utilized for storage of Cancer tissues and blood samples for various studies.
 
   
 
Laboratory- 4  
Real Time PCR:  
The instrument is utilized for diagnosis of mutated Cancer Genes.
 
   
  Animal House
 
Facilities for housing and experimentation of animals are available. An Institutional Animal Ethics Committee (IAEC) has been constituted. The animal house is registered from CPCSEA (Committee for the purpose of Control and supervision of Experiments on Animals), Ministry of Environment & Forests, Chennai for “Research & Breeding” of small animals like Mouse, Rats, Guinea pigs & Rabbits under registration number – 1129/bc/07/CPCSEA.
It is expected that this centre will undertake experiments on animals with funding from National & International agencies.

 
     
 
This institute is also recognized by Scientific and Industrial Research Organisation (SIRO) by the Department of Scientific and Industrial Research, Ministry of Science & Technology, Govt. of India under the scheme on Recognition of Scientific and Industrial Research Organisation (SIROs) – 1988
 
Collaborative research work with Rajendra Memorial Research Centre, Agamkuan, Patna is in progress.
 
Collaborative research work with Central Drug Research Institute, Lucknow is in progress.
 
Collaborative Research works with National Institute of Immunology, New Delhi is in progress.
 
Associated Research work with Department of Biochemistry, A.I.I.M.S, New Delhi is in progress.
 
MoU with A.N. College, Patna (Magadh University)
 
MoU with Central University of South Bihar (CUSB), Gaya
 
Partnership with UNICEF Bihar
 
   
 
Animal facilities for Research  
All facilities for surgery on animals
 
Haematological assay
 
Facilities for histopathology  
Hormonal assay
 
Biochemical assay
 
Probiotics study
 
Cytotoxic & genotoxic analysis
 
Microphotography &
 
Data compilation  
     
  Projects sanctioned by Government of India :
 
1.
Title : Protective effect of few medicinal plant extracts on pesticide induced reproductive disorders in mice, Sponsored by Indian Council of Medical Research, New Delhi, Govt. of India.
2.
Title : Phthalate induced effect on reproductive health & chromosomal anomalies in female swiss albino mice – Mus musculus. Sponsored by Department of Science & Technology, New Delhi, Govt. of India (Fellowship Project)
3.
Title : Estimation of pesticides and heavy metals in people of Bihar and Linkage with Cancer. Sponsored by Department of Science & Technology, New Delhi, Govt. of India.
4.
Title : Study of arsenic accumulation in people of Bihar and its correlation with arsenic induced carcinogenicity in animal models. Sponsored by Department of Science & Technology, New Delhi, Govt. of India.
5.
Title : Assessment of arsenic in the village Simri of Buxar district of Bihar. Sponsored by Department of Science & Technology, New Delhi, Govt. of India.
 
 
Members of Research Centre
  Prof. Ashok Kr. Ghosh (HOD)
  Dr. Arun Kumar (Scientist - I)
 

Dr. Mohammad Ali (Scientist - I)

 

Dr. Ranjit Kumar (Scientist - I)

 

Er. Gautam Anand (Research Assistant)

  Mr. P. K. Niraj (Research Assistant)
 
 
Contact E- mail : mcsresearch7@gmail.com
Contact Numbers: 7091490890, 7091492760(Ext. 307) (O)
9334740800, 9334643071, 9304450602

 
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